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Preeclampsia was once called “the disease of theories,” but research efforts this past decade have produced exciting breakthroughs that may bring us closer to causality, improve diagnosis and even prediction, and lead to prevention and/or specific treatments. Some speculation remains over different theories including: changes in biology of the placenta, the systemic inflammatory response, a variety of hormones and other proteins that are in the mother’s circulation, changes in immune factors, improper cardiovascular adaptations to the pregnant state, underlying maternal risks for cardiovascular disease, associations with insulin resistance and diabetes, and deficiencies in essential nutrients, minerals, and vitamins. 

The most plausible theories focus on the placenta and describe the disorder in two stages. In the first, the initiating cause results in the placenta producing factors (e.g., specific proteins, placental “debris”) that enter the maternal circulation and are believed responsible for producing the next stage. This is the second stage, which results in the overt maternal “disease” (high blood pressure, kidney, liver and coagulation abnormalities).  The overt disease depends not only on the action of the circulating factors from the placenta, but also the health of the mother, including diseases that may affect the vasculature (such as preexisting cardiovascular, renal, metabolic, and genetic factors; and obesity). A quick chart of potential causes can be found in our FAQsLong Fur Sz with M Coat Sides Leather 18xqw1rU.

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A promising area of recent research involves the role of proteins produced by the placenta that inhibit angiogenesis (the production of new blood vessels).  Two of these “antiangiogenic factors” (soluble Fms-like tyrosine kinase-1, and soluble endoglin) have been shown to produce a preeclampsia like disease in rodents. Their concentrations rise in the mother’s circulation weeks to months before the disease manifests.  Placentas of women destined to develop preeclampsia overproduce these proteins that then enter the mother’s circulation.  Neutralizing their actions is now being investigated in animal models, and in some studies has reversed the disease in rodents. .  Excitement regarding these interventions is tempered by a limited understanding of the functional role of antiangiogenic substances in normal pregnancy.

If the ability of these antiangiogenic proteins to cause preeclampsia is confirmed by research in humans, why the placenta overproduces them remains unknown. Hence, many of the other areas of investigation mentioned above may be important.  Preeclampsia may have multiple causes, and other leads are being investigated, including prostaglandins, digoxin-like molecules, immunological mechanisms, autoantibodies that trigger receptors that lead to vessel constriction (agonistic autoantibodies to the angiotensin 1 receptor), oxidative stress, mitochondrial pathology, the impact of hypertension and prehypertension on endovascular health, and genes sensitive to low oxygen environments. 

Basic research into causes of preeclampsia, lacking for decades, is being revitalized, albeit more slowly than needed. While we are moving closer to historically elusive answers, the true cause of preeclampsia remains unknown. Successful ongoing  research needs far more support and funding.

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44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H 44 military 30s wool Men brown peacoat coat overcoat army brown double long breasted Vintage 40s 42 1940s coat winter coat pea coat 1930s 6Ixqx5Ww4H
Authentic vintage antique Fire Department issued men's wool coat. Estimated 1940s-1950s coat, this is a heavy wool winter pea coat for men approximate size 42/44. Double breasted coat with gold metal brass buttons engraved with FD.







Excellent and exceptional condition, sturdy and highest quality construction. The classic cut and styling make it a great overcoat for work days or weekend wear. Grey-brown color wool with natural cotton lining.







MATERIAL: Wool with cotton lining. Brass metal buttons.







CONDITION: Appears gently or hardly ever worn.







FITS LIKE: M-L, about a 42-44 regular, based on measurements of coat:







MEASUREMENTS OF THE COAT, NOT THE PERSON, please allow for room for clothing beneath.



shoulder: 19.5



chest: 46



sleeve: 24







SHIPPING OPTIONS: This coat weighs 7 lbs, so I've listed it to ship Priority Mail international due to weight.







~VINTAGE FROM HOLLYWOOD~
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