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Preeclampsia was once called “the disease of theories,” but research efforts this past decade have produced exciting breakthroughs that may bring us closer to causality, improve diagnosis and even prediction, and lead to prevention and/or specific treatments. Some speculation remains over different theories including: changes in biology of the placenta, the systemic inflammatory response, a variety of hormones and other proteins that are in the mother’s circulation, changes in immune factors, improper cardiovascular adaptations to the pregnant state, underlying maternal risks for cardiovascular disease, associations with insulin resistance and diabetes, and deficiencies in essential nutrients, minerals, and vitamins. 

The most plausible theories focus on the placenta and describe the disorder in two stages. In the first, the initiating cause results in the placenta producing factors (e.g., specific proteins, placental “debris”) that enter the maternal circulation and are believed responsible for producing the next stage. This is the second stage, which results in the overt maternal “disease” (high blood pressure, kidney, liver and coagulation abnormalities).  The overt disease depends not only on the action of the circulating factors from the placenta, but also the health of the mother, including diseases that may affect the vasculature (such as preexisting cardiovascular, renal, metabolic, and genetic factors; and obesity). A quick chart of potential causes can be found in our FAQsa with vintage from fur jacket tailored of mink 60s One kind blue wool royal collar genuine a handmade the vPFwpq.

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A promising area of recent research involves the role of proteins produced by the placenta that inhibit angiogenesis (the production of new blood vessels).  Two of these “antiangiogenic factors” (soluble Fms-like tyrosine kinase-1, and soluble endoglin) have been shown to produce a preeclampsia like disease in rodents. Their concentrations rise in the mother’s circulation weeks to months before the disease manifests.  Placentas of women destined to develop preeclampsia overproduce these proteins that then enter the mother’s circulation.  Neutralizing their actions is now being investigated in animal models, and in some studies has reversed the disease in rodents. .  Excitement regarding these interventions is tempered by a limited understanding of the functional role of antiangiogenic substances in normal pregnancy.

If the ability of these antiangiogenic proteins to cause preeclampsia is confirmed by research in humans, why the placenta overproduces them remains unknown. Hence, many of the other areas of investigation mentioned above may be important.  Preeclampsia may have multiple causes, and other leads are being investigated, including prostaglandins, digoxin-like molecules, immunological mechanisms, autoantibodies that trigger receptors that lead to vessel constriction (agonistic autoantibodies to the angiotensin 1 receptor), oxidative stress, mitochondrial pathology, the impact of hypertension and prehypertension on endovascular health, and genes sensitive to low oxygen environments. 

Basic research into causes of preeclampsia, lacking for decades, is being revitalized, albeit more slowly than needed. While we are moving closer to historically elusive answers, the true cause of preeclampsia remains unknown. Successful ongoing  research needs far more support and funding.

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***THIS DRESS IS ONLY AVAILABLE BY SPECIAL ORDER. IT IS AVAILABLE IN YOUR CHOICE OF SIZE (ALSO AVAILABLE IN OTHER COLORS, PLAIDS AND FABRICS). OTHER LENGTHS AND SILHOUETTES ARE AVAILABLE. ALL CHANGES ARE SUBJECT TO CUSTOM CHANGE FEE.







***PLEASE NOTE THAT IF YOU NEED A DIFFERENT CLAN PLAID, IT MAY REQUIRE ADDITIONAL PRODUCTION AND SHIPPING TIME. MANY OF THE PLAID FABRICS WILL NEED TO BE CUSTOM ORDERED FROM EUROPE.***







***ALL FABRICS, CORSET STYLES AND TRIMS (INCLUDING BUT NOT LIMITED TO BROOCH STYLE WILL VARY AND DIFFER BASED UPON AVAILABILITY.***







This stunning strapless sweetheart neckline tutu style is among my newest additions here. This gown features a black corset top with and a cameo choker which is included.



.***THE CORSET IS AVAILABLE IN MANY OTHER COLORS.*** Additional brooch style substitutions/options are available for no additional charge. The skirting/bottom of the dress is made up of red wallace plaid and multiple layers of tulle adding drama and volume to this sexy, flirty dress.







This dress is also available in many other color combinations. Please allow 2 to 4 weeks for production before this item will ship. ***EXPRESS PRODUCTION AND SHIPMENT IS AVAILABLE. PLEASE EMAIL ME FOR DETAILS.***







***ONCE YOUR ORDER HAS BEEN PLACED AND YOUR CHECKOUT IS COMPLETED, THIS ITEM IS A FINAL SALE. ABSOLUTELY NO REFUNDS, RETURNS, EXCHANGES OR ADJUSTMENTS WILL BE ALLOWED. ABSOLUTELY NO EXCEPTIONS WILL BE MADE. ***10% OF THE SALE OF THIS GOWN WILL BE DONATED TO MY NEW CHARITABLE FOUNDATION WHICH WILL PROVIDE FINANCIAL ASSISTANCE FOR MEDICAL PROCEDURES FOR WOMEN WITH FEMALE RELATED ILLNESSES AND CONDITIONS.***







***NOTE*** This dress is also available with a bottom of plain tulle, taffeta, velvet, brocade, feathers, satin and many other fabrics.
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