NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn

Preeclampsia was once called “the disease of theories,” but research efforts this past decade have produced exciting breakthroughs that may bring us closer to causality, improve diagnosis and even prediction, and lead to prevention and/or specific treatments. Some speculation remains over different theories including: changes in biology of the placenta, the systemic inflammatory response, a variety of hormones and other proteins that are in the mother’s circulation, changes in immune factors, improper cardiovascular adaptations to the pregnant state, underlying maternal risks for cardiovascular disease, associations with insulin resistance and diabetes, and deficiencies in essential nutrients, minerals, and vitamins. 

The most plausible theories focus on the placenta and describe the disorder in two stages. In the first, the initiating cause results in the placenta producing factors (e.g., specific proteins, placental “debris”) that enter the maternal circulation and are believed responsible for producing the next stage. This is the second stage, which results in the overt maternal “disease” (high blood pressure, kidney, liver and coagulation abnormalities).  The overt disease depends not only on the action of the circulating factors from the placenta, but also the health of the mother, including diseases that may affect the vasculature (such as preexisting cardiovascular, renal, metabolic, and genetic factors; and obesity). A quick chart of potential causes can be found in our FAQsdress Plus Caftan Dress size Dress Dress Party Dress Dress Kaftan Oversized Black Abaya Maxi Bow Backless xzq8nt04.

34 Bow Accented Style Bridal 31815 NWT Wedding Antique with Empire Dress 1 Detachable Cathedral Size 6 Bust Train Gown 1960s
A promising area of recent research involves the role of proteins produced by the placenta that inhibit angiogenesis (the production of new blood vessels).  Two of these “antiangiogenic factors” (soluble Fms-like tyrosine kinase-1, and soluble endoglin) have been shown to produce a preeclampsia like disease in rodents. Their concentrations rise in the mother’s circulation weeks to months before the disease manifests.  Placentas of women destined to develop preeclampsia overproduce these proteins that then enter the mother’s circulation.  Neutralizing their actions is now being investigated in animal models, and in some studies has reversed the disease in rodents. .  Excitement regarding these interventions is tempered by a limited understanding of the functional role of antiangiogenic substances in normal pregnancy.

If the ability of these antiangiogenic proteins to cause preeclampsia is confirmed by research in humans, why the placenta overproduces them remains unknown. Hence, many of the other areas of investigation mentioned above may be important.  Preeclampsia may have multiple causes, and other leads are being investigated, including prostaglandins, digoxin-like molecules, immunological mechanisms, autoantibodies that trigger receptors that lead to vessel constriction (agonistic autoantibodies to the angiotensin 1 receptor), oxidative stress, mitochondrial pathology, the impact of hypertension and prehypertension on endovascular health, and genes sensitive to low oxygen environments. 

Basic research into causes of preeclampsia, lacking for decades, is being revitalized, albeit more slowly than needed. While we are moving closer to historically elusive answers, the true cause of preeclampsia remains unknown. Successful ongoing  research needs far more support and funding.

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Empire 1 Bust Bridal with Wedding Dress Gown Cathedral Antique 6 NWT Size Detachable Accented 34 Bow 31815 Train Style 1960s
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NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn NWT Gown Wedding Dress Empire Bridal with Bow 1960s 31815 1 Cathedral Train Bust Detachable Accented 6 Size Antique 34 Style Z8F4wqn
For a traditional look with vintage details, this bridal gown is a lovely choice with a net Empire bodice and bow-accented raised waist. It has a raised lace collar, sheer yoke and and beautiful bishop sleeves with fitted cuffs. Hand-sewn pearls & sequins are occasional accents throughout the lace. The gown has a broad and formal A-line skirt with a lace panel hem, and a bouffant bow with pointed tails to the back waist. Detachable train included with pleats across the top and lace at the hem. It trails about 4-5 feet behind the bride for a near-cathedral length. Original tag is attached with a $400.00 price from over forty years ago.







Ladies' Size



6 to 7







Measurements



Bust 34, Raised Waist 29; Neck to Raised Waist 13, Neck to Back Dress Hem 58, Train Length 70.5 Inches







Era



1960s







Label



' Fink / Original ' and ' Sallie's ' at back bodice







Materials



Papyrus* creamy champagne peau du soie, likely a silk blend; offwhite Alencon floral lace; beige net; trims are clear faceted sequins and two sizes of white faux pearls; net and silk organza bodice linings; papery fiber skirt lining







Closure



Center back metal zipper







Condition



Excellent







Condition Detail



Beautiful condition, never worn; the net looks and feels sturdy but may be fragile and is due careful use; back bodice has a trace 1-inch tan line at net very hard to notice; two similar barely perceptible beige specks at bow, not noticeable







Washing Instructions



Dry clean







Please note: All measurements (bust - waist - hip) are the maximum body measurements that will fit the item. These measurements already have ease subtracted and they are not actual fabric widths. To get actual fabric widths add two inches at the bust - one inch at the waist and two inches at the hip.







Size listed is a modern size. Any available vintage size is noted in the Label description. Please remember vintage sizes and modern sizes can vary a great deal.







Additional photos are often available - please message us and we'll be glad to reply.



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